2018 Achievements

THE END OF 2018 MARKS ONE YEAR SINCE THE BIRTH OF ART LAB SOLUTIONS PTY LTD. WE HAVE TAKEN THIS OPPORTUNITY TO REFLECT ON OUR ACHIEVEMENTS AND DEVELOPMENT THROUGHOUT THE YEAR:

  • Shelf life extension of the complete cattle IVF media product suite

  • Expansion of our media product range to include transport media

  • Progression of other product & service lines such as mouse embryo production media and the bovine embryo assay

  • Packaging improvements for international clients

  • Relationship development with clients and collaborators

  • Expansion of the diverse and dedicated team

  • SAECF funding awarded to support APVMA registration of our cattle IVF media products

THANK YOU!

We would like to take this opportunity to thank all of our valued clients and staff for their support throughout 2018. Wishing everyone a safe and happy Christmas and New Year. 

ART Lab Solutions will be closing from 24th December 2018 – 7th January 2019
A new batch of media will be available mid-January 2019.
Looking forward to seeing clients and friends at IETS in New Orleans 20th -23rd January 2019, come by our exhibition booth for a chat.

November’s Tip of the Month – Artificial Intelligence & Embryo Selection

Artificial Intelligence & Embryo Selection

Can we predict embryo quality using artificial intelligence?

Artificial intelligence is a hot topic – it seems as if whole industries will be transformed by the application of artificial intelligence and machine learning principles. It’s a revolution driven by the ever-increasing speeds of computer processing, but how can this relate to selecting quality embryos? One thing for certain is that animal breeding will not be immune to the application of artificial intelligence.

A current work in progress that we are researching, as well as others, is the ability of artificial intelligence to predict an embryo’s potential to form a pregnancy or not prior to transfer.  The major challenge for adoption of the IVF embryo as the preferred option for cattle breeding is the resulting slightly lower pregnancy rates.  Therefore the question that remains is whether we can use artificial intelligence to ensure only viable embryos are transferred?”

Our preliminary research results, based on 125 IVF embryo transfers, suggests we can, and with great accuracy! Stay tuned…..

For more information on this month’s tip, or any trouble-shooting queries contact admin@artlabsolutions.com

BREAKTHROUGH IN CATTLE IVP TECHNOLOGY

What is your lab’s current cattle IVP blastocyst rate from abattoir-collected oocytes?  30% from fertilized oocytes? Or is it more like 40%, or even 50%?  What about over 70%?

Have you ever seen those results over several runs, months apart?

ART Lab Solutions is announcing that we have made a breakthrough in IVP technology, where over 70% of fertilized oocytes (over 60% of all oocytes) form good quality blastocysts.  And no CO2 atmosphere or special gas mix is required for IVM, making it ideal for “Transport IVM”.

TIVM Data

Figure 1. COCs matured in Transport VitroMat for 24 hours in a 38.5°C environment. Represented as pooled data from 230 COCs over several experimental replicates.

To learn more, or to order our media, contact ART Lab Solutions at admin@artlabsolutions.com.

Transport VitroMat Product Release

In the cattle IVF industry, to collect eggs from cows at a significant distance from a central laboratory should be the most efficient, cost effective way to develop a strong IVF industry.  But that means ‘shipping’ eggs overnight from the collection site to the laboratory while letting the eggs continue their maturation processes.

ART Lab Solutions has developed a new medium, “Transport VitroMat”, that enables eggs to be matured whilst in transport.   Our new medium has produced outstanding results from abattoir-sourced eggs shipped to our laboratory from colleagues in Melbourne, Victoria.  We were amazed at the 75% viable embryo production from fertilized eggs (in the large volume group) – this is as high as even our best results obtained without transportation.

TransIVM Lrg & sml Volume

*The reference to ‘large’ and ‘small’ volumes refers to different incubation vessels used in this work. Data is representative of approx 50 COCs per group.

If you would like to discuss further about our cattle IVF products, please contact admin@artlabsolutions.com

April’s Tip of the Month – 5% O2 Vs 7% O2 for Culture

Each month we will give a tip on how to improve your results, sourced either from the literature or our own research.

5% O2 Vs 7% O2 for Culture

Why do we recommend in our protocol culturing putative zygotes to the blastocyst stage in 7% O2, rather than 5% O2?  Historically, 5% O2 was found to be optimum for mouse embryo culture.  Then H. Robin Tervit, whilst studying for his PhD at Babraham, Cambridge, UK, in 1972, demonstrated for sheep and cattle embryo development in vitro, 5% was beneficial over 20% (air). But there were no studies examining a range of O2 levels, until Jeremy Thompson and Robin Tervit published in 1990 the most comprehensive study of O2 levels and embryo development in sheep and cattle, indeed in any species, which remains so to this day.  Their results suggested the theoretical optimal O2 level is 7% for embryo culture.  This makes physiological sense, as the ruminant embryo is 30% larger in diameter compared to the mouse and more metabolically active, so a slightly higher level is likely to assist O2 diffusion.
But is 5% less effective than 7%?  There is no evidence (and proving so would be of limited interest) to claim 5% is any better or worse than 7%.  What is critical is that, for embryo culture in sheep, cattle and most other mammalian species, a low O2 environment, around 5 – 7%, is provided.
For more information on this month’s tip, contact admin@artlabsolutions.com

Local Abattoir Fire – Thomas Foods International

Thomas Foods International was the local source of abattoir-derived ovaries which ceases to operate temporarily due to a major fire. 

We expect the ovary supply to begin again in early 2019. Unfortunately this will impact our capacity to teach embryology at the University of Adelaide, South Australia. However our partner in Rockhampton, Queensland is able to offer embryology and OPU training during this time. Please continue to register your interest with us at admin@artlabsolutions.com and we will forward on your details.

March’s Tip of the Month – INCUBATORS!

Each month we will give a tip on how to improve your results, sourced either from the literature or our own research.
Q: “How many incubators do I need for my IVF program?”
A: The short answer is – whatever the number you think is necessary and then add one more!” 
The long answer, which is about the merits of what is described as “stabilised incubator space”.
Good incubators are expensive, especially those that provide low oxygen (5-7%) for embryo culture. However, ensuring that the temperature and carbon dioxide levels remain constant as much as possible is critical for good results.  Enter into any good commercial IVP laboratory, and you will see lots of incubators, all regularly monitored.  You won’t get the best out of the media you use if you don’t have enough stabilised incubator space.
For more information on this month’s tip, contact admin@artlabsolutions.com

ART Lab Solutions to launch at International Embryo Technology Society Conference 2018

To commemorate it’s official launch, ART Lab Solutions will be an exhibitor at the International Embryo Technology Society (IETS) annual conference in 2018, Bangkok, Thailand.

If you’re heading over, please ensure you come by and say hello to the ART Lab Solutions team and check out our range of products!

About International Embryo Technology Society

The IETS provides access to the most current research and clinical procedures associated with ovulation, superovulation, gonadotropins, IVM, IVF, embryonic developmental stages, oocyte cryopreservation, embryo transfer/cloning as well as the follicle, embryo, oocyte, and sperm cell.

Conference details:

Date: January 13-16, 2018
Where: Shangri-La Hotel Bangkok, Bangkok, Thailand

Co-Chairs: Trudee Fair and Daniel Salamone
THEME: “Building an Embryo: A Fertile Journey”

Find out more about the conference here.

 

Meet our Founder, Professor Jeremy Thompson

My overall research interest is the impact of the micro-environment surrounding oocytes and embryos, especially nutritional factors, within both the in vivo (follicular/oviduct/uterine) and in vitro environment. This encompasses the following research:

Hypoxia, Hypoxia inducible factors and their role in reproduction

My laboratory has had a long standing interest in the role of oxygen concentration in regulating events within the female reproductive tract. This is primarily because both oocytes (within follicles) and pre-implantation stage embryos (especially within the uterus) develop in what is normally considered low oxygen concentration environments. We have focussed on the role of the transcription factor, Hypoxia Inducible Factor, in regulating a number of transitional events, such as follicle antrum formation, corpus luteum formation, early embryo development and implantation.

Read Jeremy’s Profile here: https://researchers.adelaide.edu.au/profile/jeremy.thompson