Our breakthrough in IVP technology
With our media, over 70% of fertilised oocytes form good quality blastocysts.
The high development rate from our media is a result of over 35 years of research, development and industry consultation, led by the company’s founder, Professor Jeremy Thompson.
Industry standard rates rarely exceed 40%.
How do we compare to others?
See our independent results from Europe!
One of our European clients recently compared three commercially available bovine IVP media options under their own laboratory conditions. We were very pleased to see ART Lab Solutions achieve the highest blastocyst rate of the three media systems tested:
ART Lab Solutions – 51.69%
Commercial Media Provider 1 – 22.20%
Commercial Media Provider 2 – 48.16%
What makes these results particularly valuable is that the comparison was conducted independently by a client using the media in a real-world IVP laboratory setting. For us, this is exactly what matters, developing media that delivers consistent, high-quality embryo development where it counts. In our customers’ laboratories.
A great result for Australian-developed and manufactured bovine IVF technology competing on the global stage.
Bovine Embryo Development Results
The high development rate >47% blastocyst development from oocyte number, >60% blastocyst development from cleaved number of embryos is a result of over 30 years of research, development and industry consultation led by the company’s founder Professor Jeremy Thompson.
Industry standard rates rarely exceed 40% blastocyst development from cleaved embryos.
Graph represents percent blastocyst development from oocytes and cleaved embryos via bovine embryo assays performed externally by an independent laboratory in Australia. Representative of 909 COC’s over several replicates. COC’s were aspirated from abattoir-derived ovaries and cultured in a serum free system using ART Lab Solutions complete bovine media suite. Zygotes were then cultured in vitro until day 8 of embryo development, cleavage and blastocyst rates were recorded.
Quality Control & Results
Quality is central to everything we manufacture at ART Lab Solutions. Our media undergoes rigorous quality-control processes to ensure consistency, performance and reliability before release.
As part of our quality program, we use Osmolality (mOsm/kg), pH at 38.5°C, and performance of a Bovine Embryo Assay (BEA) to assess the suitability of media and selected laboratory materials for use in bovine embryo production. By evaluating their effect on embryo development under controlled laboratory conditions, the BEA provides a biologically relevant measure of performance and helps identify materials or products that may adversely affect embryo development.
ART Lab Solutions also offers Bovine Embryo Assay testing as a service to laboratories, researchers and industry partners requiring independent biological assessment of media, consumables or other materials used within the IVF laboratory.
Bovine Embryo Assay
Our Bovine Embryo Assay is performed using a serum-free in vitro production system and oocytes recovered from abattoir-derived bovine ovaries. Following maturation and fertilisation, embryos are cultured through to Day 8, allowing developmental performance to be assessed across the full pre-implantation culture period. This provides a sensitive biological measure of the suitability of media, consumables and laboratory materials for bovine IVF and embryo culture, helping us identify potential issues before products reach the customer. By maintaining this level of biological quality control, we aim to support consistent embryo development, reliable laboratory performance and the best possible outcomes for our customers, their embryos and ultimately the long-term success of their breeding programs.
To obtain a copy of our Certificate of Analysis for any batch of media please contact us directly.
Papers using our founder Professor Jeremy Thompson’s formulated cattle in vitro embryo production media
We have a repository of Cattle IVP Embryo papers featuring our Founder Jeremy Thompson, supporting ART LAB Solutions media development.
- Monteiro, C.A.S., Chow, D.J.X., Leal, G.R, Tan, T.CY.,Ferreira, A.M.R., Thompson, J.G (2021) Optical imaging of cleavage stage bovine embryos using hyperspectral and confocal approaches reveals metabolic differences between on-time and fast-developing embryos. Theriogenology. 159:60-68.
- Whitty, A., Kind, K.L., Dunning, K.R., Thompson, J.G. (2021) Effect of oxygen and glucose availability during in vitro maturation of bovine oocytes on development and gene expression. Assisted Reproduction and Genetics. 38: 1349-1362.
- Soto-Heras, S., Paramio, M.T., Thompson, J.G (2019) Effect of pre-maturation with C-type natriuretic peptide and 3-isobutyl-1-methylxanthine on cumulus-oocyte communication and oocyte developmental competence in cattle. Animal Reproduction Science. 202:49-57.
- Sutton-McDowall, M.L., Gosnell, M., Anwer, A.G., White, M., Purdey, M., Abell, A.D., Goldys, E.M. and Thompson, J.G. (2017) Hyperspectral microscopy can detect metabolic heterogeneity within bovine post-compaction embryos incubated under two oxygen concentrations (7% versus 20%). Human Reproduction. 32:2016–2025.
- Li, H.J., Sutton-McDowall, M.L., Wang, X., Sugimura, S., Thompson, J.G.and Gilchrist, R.B. (2016) Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions. Human Reproduction 31:810-821.
- Sutton-McDowall, M.L., Lu, L.L.Y., Purdey, M., Abell, A.D., Goldys, E. MacMillan, K.L., Thompson, J.G. and Robker, R.L. (2016) Nonesterified fatty acid-induced endoplasmic reticulum stress in cattle cumulus oocyte complexes alters cell metabolism and developmental competence. Biology of Reproduction 94(1):23. doi: 10.1095/biolreprod.115.131862.
- Sutton-McDowall, M.L., Purdey, M., Brown, H.M., Abell, A.D., Mottershead, D.G., Cetica, P.D., Dalvit, G.C., Goldys, E.M., Gilchrist, R.B., Gardner, D.K. and Thompson, J.G. (2015) Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Molecular Reproduction and Development. 82:281-94.
- Sugimura, S., Ritter L.J., Rose R.D. and Thompson J.G., Smitz J., Mottershead D.G., Gilchrist R.B. (2015) Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes. Developmental Biology. 403:139-49.
- Machado, M.F., Caixeta, E.S., Sudiman, J., Gilchrist, R.B., Thompson, J.G., Lima, P.F., Price, C.A. and Buratini, J. (2015) Fibroblast growth factor 17 and bone morphogenetic protein 15 enhance cumulus expansion and improve quality of in vitro-produced embryos in cattle. Theriogenology 84:390-398.
- Green, M.P., Harvey, A.J., Spate, L.D., Kimura, K., Thompson, J.G. and Roberts, R.M. (2015) The effects of 2,4-dinitrophenol and D-glucose concentration on the development, sex ratio, and interferon-tau (IFNT) production of bovine blastocysts. Molecular Reproduction and Development 83: 50-60.
- Thompson, J.G., Gilchrist, R.B., McDowall, M.L. (2014) Metabolism of the bovine cumulus oocyte complex revisited. In: “Reproduction in Domestic Ruminants VIII”L. Juengel, A. Miyamoto, C. Price, L.P. Reynolds, M.F. Smith, R. Webb, pp 311-326. Context Products, Leicestershire, UK.
- Sutton-McDowall, M. L., Yelland, R., Macmillan, K. L., Robker, R. L. and Thompson, J. G. (2014) A study relating the composition of follicular fluid and blood plasma from individual Holstein dairy cows to the in vitro developmental competence of pooled abattoir-derived oocytes. Theriogenology 82:95-103.
- Sudiman, J., Sutton-McDowall, M.L., Ritter, L.J., White, M.A., Mottershead, D.G., Thompson, J.G., Gilchrist, R.B. (2014) Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PLoS One. 2014 Jul 24; 9(7):e103563.
- Sugimura, S., Ritter, L. J., Sutton-McDowall, M. L., Mottershead, D. G., Thompson, J. G. and Gilchrist, R. B. (2014) Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply. Molecular Human Reproduction. 20:499-513.
- Morado, S., Cetica, P., Beconi, M., Thompson, J. G., Dalvit, G (2013). Reactive oxygen species production and redox state in parthenogenetic and sperm-mediated bovine oocyte activation. Reproduction 145: 471-478.
- Caixeta, E. S., Sutton-McDowall, M. L., Gilchrist, R. B., Thompson, J. G., Price, C. A., Machado, M. F., Lima, P. F., Buratini, J. (2013). Bone morphogenetic protein 15 and fibroblast growth factor 10 enhance cumulus expansion, glucose uptake, and expression of genes in the ovulatory cascade during in vitro maturation of bovine cumulus-oocyte complexes. Reproduction 146: 27-35.
- Gutnisky, C., Dalvit, G.C., Thompson, J.G., Cetica, P. (2013) Pentose phosphate pathway activity: Effect on in vitro maturation and oxidative status of bovine oocytes. Reproduction, Fertility and Development. 26: 931-942.
- Gutnisky, C., Morado, S., Dalvit, G. C., Thompson, J. G., Cetica, P. D. (2013). Glycolytic pathway activity: effect on IVM and oxidative metabolism of bovine oocytes. Reproduction, Fertility and Development 25: 1026-1035.
- Sutton-McDowall, M.L., Feil, D., Robker, R.L., Thompson, J.G., Dunning, K.R. (2012) Utilisation of endogenous fatty acid stores for energy production in bovine pre-implantation embryos. Theriogenology 77:1632-41.
- Sutton-McDowall, M.L., Mottershead, D.G., Gardner, D.K., Gilchrist, R.B., ThompsonG. (2012) Metabolic differences in bovine cumulus oocyte complexes matured in vitro in the presence or absence of follicle stimulating hormone and bone morphogenetic protein 15. Biology of Reproduction 87: (87)1-10.
- Albuz F.K., Sasseville M., Lane M., Armstrong D.T., Thompson J.G., Gilchrist R.B. 2010. Simulated physiological oocyte maturation (SPOM): A novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes. Human Reproduction 25: 2999-3011
- Hussein, T.S., Sutton-McDowall, M.L., Gilchrist, R.B., Thompson, J.G. (2011) Temporal effects of exogenous oocyte-secreted factors on bovine oocyte developmental competence during IVM. Reproduction, Fertility and Development 23: 576-84
- Lopes A.S., Lane M., Thompson J.G. (2010) Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes. Human Reproduction 25: 2762-2773
- Irving-Rodgers, H.F., Morris, S., Collett, R.A., Peura, T.T., Davy, M., Thompson, J.G., Mason, H.D., Rodgers, R.J. (2009) Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes. Human Reproduction 24:936-44
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We deliver reproductive technologies that accelerate the improvement of livestock quality, and we’d like to help you do just that.