Excitement vs. pragmatism: Where does AI sit within cattle IVF embryology?

Written by Prof. Jeremy Thompson

There’s a buzz in the field of human IVF concerning the application of AI and automation to bring efficiency and standardisation of procedures conducted by clinical embryologists. The most advanced areas are live sperm quality separation and AI-assisted embryo quality assessment. Nevertheless (and with most innovation in the field), the large-scale trials providing conclusive evidence that real benefits are achieved are still to begin, or at best, are in early stages of clinical adoption. However, there is a lot of innovation occurring through brands or companies such as Life Whisperer, MIM Fertility, IdaScore, ZyMot, Memphasys, Conceivable, Fertilis, AutoIVF, Overture Life, just to name a few. But is any of this relevant to cattle IVF? Well, yes and no. Firstly and most obviously, the drivers for innovation commercialisation are completely different between the two; human IVF is driven by the need to solve the real pain of infertility, and therefore is a personal, emotional journey for those experiencing it, whereas cattle IVF is a pragmatic solution to providing rapid genetic gain (and therefore increasing profit margins with the least additional expenditure). However, the two fields have similarities and common challenges, not the least is that both are booming in demand for services, and the demand is outstripping the capability to service the demand. And one of these constraints is the number of skilled embryologists.

Nevertheless, I am surprised by how rapid the growth of cattle IVF has been over the past decade. I suggest that there is more interest because there is far more genetic testing occurring in cows than what occurred a decade ago, along with the significantly greater opportunity for more calves from multiple sires and a single cow over a year.

I remember well the meeting I had with a meat industry body some 15 years ago where they proclaimed no interest in IVF (then) because there was little to no genetic selection in beef breeds. The same industry body is now much more engaged. Yet the challenges of reduced embryo survival on transfer, along with the competence to perform vitrification well in the field, are still major problems for cattle IVF. This is where AI and automation could fit well, so long as the cost-benefit ratio is improved. The most significant opportunity is grading embryos prior to transfer, which is already clinically established, albeit with little evidence of improvement over a skilled clinical embryologist but is most likely faster than the embryologist. Pregnancy rates from cattle IVP embryos remain lower (50%- 55%) relative to MOET derived embryos (65%). In clinical IVF, the grading systems are aimed at selecting the best embryo, for the first fresh transfer, then the next (to vitrify), etc. This is because patients want to achieve a pregnancy as soon as possible. For cattle IVF, I have always maintained that we should be selecting for the embryos that have low to no chance of forming a pregnancy and exclude these and therefore train the AI systems to reduce the numbers of embryos. This clearly differs from the clinical scenario. However, there is an immediate data problem. Cattle IVF operations don’t normally take images of embryos, so where is the data going to come from to develop the algorithms? I have experienced the disruption in workflow that is created by having cattle embryo images taken before transfer. And the number of images to build and test algorithms is in the thousands. So pragmatism suggests that unless there is a major investment in time and effort by some (industry) group, we will continue to rely on the skill of embryologists to select cattle embryos for transfer.

ART Lab Solutions provides high-quality serum-free media to support IVF in cattle breeding programs. Our media is designed to optimise embryo development while eliminating the variability of serum, ensuring consistency, safety, and success in embryo production.

To view our products, visit: IVP Media Solutions for the Production of Cattle IVF Embryos .

For more information contact us admin@artlabsolutions.com

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